NUMB3RSisadramaaboutFBIagentDonEppes(RobMorrow),whorecruitshismathematical-geniusbrother,Charlie(DavidKrumholtz)tohelptheBureausolveawiderangeofchallengingcrimesinLosAngeles.Thetwobrotherstakeonthemostconfoundingcriminalcasesfromaverydistinctiveperspective.　　　　Inspiredbyactualcases,theseriesdepictshowtheconfluenceofpoliceworkandmathematicsprovidesunexpectedrevelationsandanswerstothemostperplexingcriminalquestions.　　　　AdedicatedFBIagent,Doncouldn'tbemoredifferentfromhisyoungerbrother,Charlie,abrilliantmathematicianwho,sincehewaslittle,hasyearnedtoimpresshisbigbrother.Asaseasonedinvestigator,Dondealsinhardfactsandevidence,whereasCharlie,amathprofessorataCaliforniauniversity,functionsinaworldofmathematicalprobabilityandequations.　　　　Now,despitetheirdisparateapproachestolife,DonandCharlieareabletocombinetheirareasofexpertiseandsolvesomekillercases.